Gabapentin and pregabalin are two medications that are commonly used for neuropathic pain. They usually takes a few weeks for it to work and can be taken either as a tablet or a liquid.

It is important not to exceed dosing instructions. Some people worry that they will become addicted to these medications – this is rare when it is used correctly to manage pain. If you do wish to reduce your dose, it is best to do so gradually under your doctor’s supervision. This is because stopping suddenly can lead to severe physical withdrawal symptoms, including increased pain, anxiety, difficulty sleeping, sweating, and even seizures.

For more information, please see the NHS pages on gabapentin and pregabalin.

To prevent side effects, your doctor will start by prescribing a low dose, which they will increase over a few days. Side effects are usually mild and resolve by themselves, but can include:

• Drowsiness.
• Sickness: try to take gabapentin with or after a meal or snack, as well as drinking plenty of fluids to avoid dehydration.
• Diarrhoea.
• Dry mouth.
• Weight gain.
• Headaches.
• Mood changes: please speak to your GP – they may be able to change you to a different medication.
• Blurred vision: avoid driving, cycling, or using tools or machinery if this occurs. Please speak to your doctor if this lasts for more than 2 days.
• Difficulty getting an erection: please speak to your doctor if you experience this.

Gabapentin and pregabalin can lead to potentially serious side effects. If you experience any of the following, please contact NHS24 on 111 immediately:

• Thoughts or harming yourself or trying to end your life. 
• Signs of a serious reaction, which include: a high temperature, swollen glands in your neck, your skin and/or the whites of your eyes turning yellow, unusual bruises or bleeding, weakness, or unexpected muscle pain or weakness.
• Persistent stomach pain, nausea, or vomiting.
• Muscle pain or weakness if you are having dialysis treatment for your kidneys.
• Seeing or hearing things that are not there (also known as hallucinations).